The hotel is owned by Kew Green Hotels, which operates 17 hotels under franchise agreements.
The hotel near the M1 junction 14 is one of 11 Courtyard by Marriott hotels in the UK to rebrand under a 20-year licence agreement with InterContinental Hotels Group plc.
All current employees will be retained and additional staff may be employed at the hotel, said a Kew Green statement.
The hotel will undergo a refurbishment programme in which banqueting suites will be upgraded, air-conditioning will be installed in all bedrooms within the next 18 months, as well as the introduction of room service breakfast and a time saving â€˜breakfast check-outâ€™.
KGH felt that the Holiday Inn brand was more appropriate for the hotel.
Courtyard by Marriott general manager David Jones said: “We are delighted to be rebranding as a Holiday Inn, as the brand is a perfect fit for this hotel.”
InterContinental Hotels Group chief executive Andrew Cosslett said: “The conversion of these hotels to Holiday Inn marks another significant win for IHG and recognises the strength of the Holiday Inn brand.
“We continue to see it grow in key strategic markets around the world as the demand for quality hotel accommodation rises.”””