A total 1,355 set up in the first half of this year, compared to 1,223 in the same period in 2011.
Duport.co.uk managing director Peter Valaitis said: “As the town continues to develop, there should be ample opportunity for business start-ups to grow and prosper.
"The next decade promises to be an exciting one for Milton Keynes, making it a great place to start a new business and watch it grow with the city.”
