The opening party, on October 27 and 28, will unveil the branch in Castle Street to personal and business customers.
Luton Mayor Cllr Mohammad Ayub said: “The fact that around 25 staff have been recruited locally is another boost to the town and proof that our ambitious £1.5 billion Luton Investment Framework is attracting business of all types.
“As we continue to develop skills and training within our community I am confident others will be able to take advantage of the sort of opportunities organisations such as Metro Bank provide.”
The bank’s managing director of retail banking Iain Kirkpatrick added: “We are thrilled to be bringing a brand new store to Luton and this time, another one of our drive-thru banks.
“For us, it is all about creating fans, so we really focus on providing a superior banking experience.”